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About Me


DJane Erika

 


ERIKA ROSIVATZ

    since MARCH 2011: Project Manager of the Institute of Chemical Biology Doctoral Training Centre at Imperial College London.

    2009-2011: Scientific Project Manager at the Centre for Toxicology, School of Paharmacy, London for a European funded FP7 project (CONTAMED) exploring chemical pollution and it's effects on male reproductive health.

    2004-2009: Post-doc position at Imperial College London, UK Division of Cell and Molecular Biology in Rudiger Woscholskis lab.

    2000 – 2004: Ph.D. at the Institute of Pathology , Technical University of Munich , Germany “Epithelial-Mesenchymal Transition Regulators in Human Cancer”

    1995 - 2000 studies of biology / microbiology at the University of Innsbruck, Austria; diploma thesis: "The Influence of PKCe on Gene Expression"

    1976 born in Braunau am Inn, Austria

    Research Interests: Phosphoinositide dependent cellular signalling with a main focus on 5-phosphatases (imaging, in vivo substrates and localisation) and mitochondrial phosphoinositides. Endocrine Disruption, Pesticides and other environmental pollutants and their effects on human health.

PUBLICATIONS:

[1] Co-author of the "Interim Report: Summary of the State of the Science on Endocrine Disruptors" for a study commissioned byt the Directorate-General for the Environment to provide a basis for:

i) the development of scientific criteria for the identification of endocrine disruptors; and

ii) the review and possible revision of the Community Strategy.

[2] Orton F, Rosivatz E, Scholze M, Kortenkamp A. Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ Health Perspect. 2011 Jun;119(6):794-800.

[3] Rosivatz E, Woscholski R. Removal or masking of phosphatidylinositol(4,5)bisphosphate from the outer mitochondrial membrane causes mitochondrial fragmentation. Cell Signal. 2011 Feb;23(2):478-86.

[4] Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest. 2010 Mar 1;120(3):681-93.

[5] Ho KK, Rosivatz E, Gunn RM, Smith ME, Stavropoulou AV, Rosivatz E, Numbere MG, Wong JB, Lafitte VG, Behrendt JM, Myatt SS, Hailes HC, Woscholski R, Lam EW. The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenylacetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells. FEBS J. 2009 Jun 22.

[6] Garczarczyk D, Toton E, Biedermann V, Rosivatz E, Rechfeld F, Rybczynska M, Hofmann J. Signal transduction of constitutively active protein kinase C epsilon.Cell Signal. 2009 Jan 9.

[7] Rosivatz E , Woscholski R. Measurement of PTEN activity in vivo by imaging phosphorylated Akt.Methods Mol Biol. 2009;462:213-22.

[8] Mulet X, Rosivatz E, Ho KK, Gauthé BL, Ces O, Templer RH, Woscholski R. Spatial localization of PtdInsP2 in phase-separated giant unilamellar vesicles with a fluorescent PLC-delta 1 PH domain.Methods Mol Biol. 2009;462:135-44.

[9] Busch GK, Tate EW, Gaffney PR, Rosivatz E, Woscholski R, Leatherbarrow RJ. Specific N-terminal protein labelling: use of FMDV 3C(pro) protease and native chemical ligation. Chem Commun (Camb). 2008 Aug 7;(29):3369-71. Epub 2008 Jun 25.

[10] Rosivatz E . Imaging the boundaries—innovative tools for microscopy of living cells and real-time imaging. J Chem Biol. 2008 in press.

[11] Ho KK, Anderson AA, Rosivatz E, Lam EW, Woscholski R, Mann DJ. Identification of cyclin A2 as the downstream effector of the nuclear phosphatidylinositol 4,5-bisphosphate signalling network. J Biol Chem . 2007 Dec 12.

[12] Becker KF, Rosivatz E, Blechschmidt K, Kremmer E, Sarbia M, Hofler H. Analysis of the E-cadherin repressor Snail in primary human cancers. Cells Tissues Organs. 2007;185(1-3):204-12.

[13] Rosivatz E. Inhibiting PTEN. Biochem Soc Trans. 2007 Apr;35(Pt 2):257-9.

[14] Castro Alves C, Rosivatz E, Schott C, Hollweck R, Becker I, Sarbia M, Carneiro F, Becker KF. Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E-cadherin. J Pathol. 2007 Apr;211(5):507-15.

[15] Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EW, Vilar R, Woscholski R. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol. 2006 Dec 15;1(12):780-90.

[16] Byrne RD , Rosivatz E, Parsons M, Larijani B, Parker PJ, Ng T, Woscholski R. Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha. Cell Signal . 2007 Feb;19(2):321-9.

[17] Becker K.-F., Rosivatz E., Blechschmidt K., Kremmer E., Sarbia M., Höfler H.. Analysis of the E-cadherin repressor Snail in primary human cancers. Cells Tissues Organs . 2007; 185( 1-3): 204-12.

[18] Rosivatz E. Interactions of Synaptojanin . Review Article. Signal Transduction. 2006;6;101-111.

[19] Rosivatz E , Becker KF, Kremmer E, Schott C, Blechschmidt K, Hofler H, Sarbia M. Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract. Virchows Arch. 2005 Nov 17;:1-11

[20] Fuchs M, Hermannstadter C, Specht K, Knyazev P, Ullrich A, Rosivatz E, Busch R, Hutzler P, Hofler H, Luber B. Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3. J Cell Physiol. 2005 Mar;202(3):805-13.

[21] Rosivatz E , Becker I, Bamba M, Schott C, Diebold J, Mayr D, Hofler H, Becker KF. Neoexpression of N-cadherin in E-cadherin positive colon cancers. Int J Cancer. 2004 Sep 20;111(5):711-9.

[22] Kremer M, Quintanilla-Martinez L, Fuchs M, Gamboa-Dominguez A, Haye S, Kalthoff H, Rosivatz E, Hermannstadter C, Busch R, Hofler H, Luber B. Influence of tumor-associated E-cadherin mutations on tumorigenicity and metastasis. Carcinogenesis. 2003 Dec;24(12):1879-86.

[23] Fricke E, Keller G, Becker I, Rosivatz E, Schott C, Plaschke S, Rudelius M, Hermannstadter C, Busch R, Hofler H, Becker KF, Luber B. Relationship between E-cadherin gene mutation and p53 gene mutation, p53 accumulation, Bcl-2 expression and Ki-67 staining in diffuse-type gastric carcinoma. Int J Cancer. 2003 Mar 10;104(1):60-5.

[24] Rosivatz E , Becker I, Specht K, Fricke E, Luber B, Busch R, Hofler H, Becker KF. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol. 2002 Nov;161(5):1881-91.

CONTACT

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